The Sira Debates

Weekly email clinical topic discussions. Respondents are a mixture of consultants, trainees and ANP’s.

Feel free to suggest a topic for debate.

All responses are personal opinions only.


Next:

Dear all, It is approaching nearly 17 years since the seminal ARDS net paper and the majority of units continue to abide by these ventilator rules or their derivatives. This week’s questions:

Are all the components of the LPV bundle equal? In other words what do we now know about ventilation since The Paper, and should our focus now change?


Previous:

CARDIOVASCULAR

Albumin in adult ICU

CTB after OOHCA

CTB in OOHCA & rhabdo management

IV Antihypertensives

NICOM’s

Statins in ICU

GASTRO/NUTRITION

Early enteral nutrition

HAEMATOLOGY

Iron deficiency anaemia in crit care

HEPATOLOGY

ICH in ALF

INFECTION CONTROL

Preventing CVC infection

PCT

NEUROLOGY

Devastating Brain Injury

Neurological prognosis after cardiac arrest

Neurosurgery – decision to operate

ICP Monitoring

NON CLINICAL

Quality in ICU

RECOVERY

De-resuscitation

Weaning

RENAL

Metabolic Alkalosis

Sodium derangement and RRT

When to start RRT

RESPIRATORY

Asthma

Minitrachs & mucolytics

Permissive hypoxia

Ventilatory Recruitment

Ventilation of a hypoxic patient with non-ARDS lung disease

SEPSIS

Beta blockers in sepsis

Bicarbonate in sepsis/acidosis

AF in sepsis

Antibiotic timing in sepsis

Temperature management in ICU

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3 thoughts on “The Sira Debates

  1. James,

    Walkley et al did quite a nice, easy to read review in Chest (2015).

    In summary:

    – There are no real major trials in the area, and pretty much all evidence is single-centre small stuff, expert opinion, or extrapolated from the non-critically ill.

    – None of the antiarrhythmics have been proven to be conclusively superior, IV Diltiazem was superior to IV Amiodarone in achieving rate control (rate reduction of 30% or <120), at the expense of more hypotension, with 30% of the Diltiazem group requiring the drug to be stopped prematurely. In another small study (n=50) Amiodarone infusion had a higher rate of reversion to sinus rhythm than Digoxin at 24 hours (92 v 71%, p=0.048) with a shorter median time to reversion (2.5 v 6.8 hours). It is worth noting that this trial was in a coronary ICU, but half of the patients had class III or class IV failure and none appeared to have systemic sepsis which limits its generalisability somewhat. IV Magnesium was shown to be superior to Amiodarone in a small Australasian study (n=42) of critically patients with respect to conversion to sinus rhythm.

    – The authors of the review put a lot of faith in a small study that showed that an IV Esmolol infusion was associated with improved mortality in patients with septic shock, and recommended Esmolol as their first-line agent for rate control. I believe this study's findings should be interpreted with caution; given its single centre, primary outcome of whether Esmolol lowered the heart rate (mortality was a secondary outcome) and high mortality in both arms of the study (Esmolol 49.4% v 80.5% in the control arm). I'm not sure I would agree that Esmolol is so great without more evidence to support it.

    – The authors fairly uncontroversially recommended correcting reversible causes for AF with rate control recommended over rhythm control where patients aren't compromised. DCCV appears to have fairly poor success in Sepsis-induced AF, but is recommended (mostly expert opinion) where patients have significant compromise.

    – In terms of anticoagulation, there is a demonstrable increase in stroke risk with AF+Sepsis (0.2%/day) but septic patients can be coagulopathic so the authors decided to sit on the fence and recommend an individual risk-benefit analysis. Which seems fairly reasonable for most things.

    – One thing that does seem worth changing in practice is following up patients who developed AF in Sepsis as recurrence appears relatively common and may well be asymptomatic. It seems that much like CKD patients being followed up a nephrologist, AF follow up by a cardiologist may reveal a number with paroxysmal AF who would potentially benefit from anticoagulation in the longer term.

    – I think one thing that also should be considered is whether we are also iatrogenically inducing AF in some patients with noradrenaline. The SEPSISPAM trial, although conducted with a degree of gallic laissez-faire did show that more patients developed AF in the low MAP target (65-70mmHg v 80-85mmHg). Although in reality the study was more like 70-75mmHg v 85-90mmHg due to protocol violations, receiving more Noradrenaline didn't improve your survival and did increase your chance of AF (although it reduced your risk of requiring RRT if you had CKD).

    Brian

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